The proposed method has been tested using the bacterial (3891 KB bases) and human chromosomal sequences (Chr-18: 74366 kb and Chr-Y: 25554 kb) and the computation time for finding the palindromic sequences is in milli seconds.Ĭomplimentarity Even-numbered Genome Palindrome. One of the primary functions of palindromic sequences in DNA is to provide a site for DNA replication. Palindrome sequences are important in bioinformatics understanding, it helps us to extract patterns in the genomic sequences. The new method uses less memory and thereby it increases the overall speed and efficiency. Inverted repeats are close cousins of palindromes. Microhomology at the breakpoints is shown as bold letters. Uppercase letters represent unique sequences. Several questions are addressed in this work. Results In this work, we tried to revisit this relatively neglected phenomenon. However, our knowledge about their evolutionary origin and their possible importance is incomplete. In each of the aligned breakpoint sequences, lowercase letters are Repeat-masker masked sequences. It has been previously shown that palindromic sequences are frequently observed in proteins. Sequence analysis of the palindromic junctions identified 7 novel junctions. Thus, a new method has been developed using dynamic programming to fetch the palindromic nucleic acid sequences. An exact palindrome is one in which there is no asymmetry in the centre or mismatch in any part of the sequence, such that its reverse compliment reads the same as the original sequence itself 3. Schematics and sequence of palindrome junctions. A typical nucleotide palindromic sequence would be TATA (5' to 3') and its complimentary sequence from 3' to 5' would be ATAT. Palindromes that occur on opposite strands of the same section of DNA helix Figure 9.10. ' able was I ere I saw elba ' is a palindrome. For example, both the strands i.e the strand going from 5' to 3' and its complementary strand from 3' to 5' must be complementary. A palindrome is a sequence of letters and/or words, that reads the same forwards and backwards. For a nucleotide sequence to be considered as a palindrome, its complementary strand must read the same in the opposite direction. Among these sequences, palindromic nucleic acid sequences are one such type that have been studied in detail and found to influence a wide variety of genomic characteristics. Various types of sequences in the human genome are known to play important roles in different aspects of genomic functioning.
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